Siddha system of medicine is a traditional system of Indian medicine. In Siddha medicines herbal formulations have no side effects and some herbs naturally have anti-oxidant property. To prove scientifically qualitative and quantitative analysis carried out to prove the active constituents. Kattu maantha kudineer study results proves it contain anti-oxidant activity by using DPPH assay, physicochemical, biochemical analysis and determination of total phenolic content were carried out. The study results also proves the presence of iron, zinc, calcium, starch, reducing sugar.

The plant Japa botanically identified as Hibiscus rosa-sinensis Linn. Of the family malvaceae.is a glabrous shrub widely cultivated in the tropics as an ornamental plant and has several forms with varying colors of flowers. In medicine, however, the red flowered variety is preferred. In this article an attempt has been made to review on Japa from different classical texts. The parts used are Flowers, leaves and root and it is very effective in indraluptanashana (alopecia areata), garbhanirodhaka (anti-implantation), Pramehaghna (anti-diabetic), jvara (fever) etc. and many of the formulations like japataila, Chemparuthyadikeratailam, Vidangadi yoga etc. contains it as a one of the ingredient.

The main objective of the present research work is to formulate the Tolmetin Extended Release Tablets. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) that is effective in treating fever, pain, and inflammation in the body. Tolmetin blocks the enzyme that makes prostaglandins (Cyclo-oxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. At present the tablets are available in the market uses as multi unit particulate systems to deliver the drug at a controlled rate over 24 hours. The present research endeavor was directed towards the development of Extended Release Tablets to be taken twice daily. The formulation of Tolmetin extended release Tablet is important to give prolonged activity in the prolonged drug release in an Extended Period of Time for the Long Term Therapeutic activity. The Formulation of the extended Released Tablets were prepared by using Suitable Excipients such as Hydroxypropyl methylcellulose; HPMC E3, HPMCK15M, HPMC K100M, hydroxy Ethyl Cellulose, povidone, colloidal silicone dioxide, Magnesium Stearate. This Tolmetin extended release tablets were prepared by using Wet Granulation Method. The Prepared extended release Tablet is Evaluated In terms of bulk density, tapped density, angle of repose, Carr’s Index and, hardness test, weight variation test, variability test and in vitro study. The hardness, weight variation, and friability these values are within the pharmacopeia limit. The finalized formulation was subjected for in vitro dissolution and compared with the innovator (TolectinR600) to produce an equivalent product and stability studies performed at 400C / 75% for 2 months. Stability samples were evaluated initially and after 2 months. The results were compared with the pre-determined specifications. All the results were found to be satisfactory.

Drug-resistance infections have increased extremely quickly in the past years, emerging as a serious health problem in the world. Novel and better antimicrobial agents are still being developed to control associated microorganisms. However, this still represents a great challenge for antimicrobial agents. The aim of this study was to evaluate their antimicrobial properties against various Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) Gram - negative bacteria: (Escherichia coli) and fungi (Candida albicans, Aspergillus flavus). The results of this experiment suggest that biologically synthesized AgNPs are fairly ideal candidates for the development of new antimicrobial drugs against bacteria and fungi.

The herbal formulation Karappan Marundhu is used for skin disease particularly for eczema. Siddha medicines are very effective in the treatment of dermatological conditions. Hence to document the safety of the drug, toxicity study has been conducted in rats following OECD guidelines. Acute toxicity studies, were carried out on female wistar albino rats as per OECD guidelines 423 and the repeated oral toxicity study was carried out on wistar albino rats of both sex as per OECD guidelines 407. Acute oral toxicity study of KM revealed no mortality at the dosage of 2000 mg/kg body weight and the median lethal dosage of KM is estimated to be above 2000mg/kg body weight. Repeated oral toxicity study of KM does not exhibit any mortality even at the high dosage of 90 mg/kg body weight during the 28 days of drug administration period in the rats. At the end of 28 days no specific changes are observed in hematological, hepatic, renal and other biochemical parameters. No gross morphological changes were observed in the organs. The KM was found to be safe in animals. No toxic effect was observed of Karappan Marundhuin acute and sub-acute toxicity studies. The above studies recommend that KM is a safest drug under intended clinical dosage in human (500mg) as illustrated in the literature Agasthiyar 2000.