Vernonia cinerea (L.) Less a member of family compositae (Asteraceae), is an important medicinal plant has already been in used as antibacterial, Analgesic, antipyretic, anti-inflammatory preparation. In this study an attempt of the plant has been made to evaluate the anticancer activity of the methanolic extract of the plant, as stated in many hypothesis. The methanolic extract of leaves of Vernonia cinerea L. were screened for their anticancer activity by in vivo the various parameters such as heamatological studies and protein estimation, solid tumor volume, median survival time (MST), life span (%LS) and in vitro studies was carried out by two methods Tetrazolium salt assay and Tryphan blue dye exclusion method. The changes in hematological parameters in mice altered significantly (p>0.01) compare to the control. There was increase the %LS (57.43), MST (36.40) and solid tumor volume was reduced significantly (p>0.01) compare to the control. In the case of MTT Assay the total growth inhibition (TGI) of methanol extract was found to be >10 mg/ml on both cell lines (HEp 2 and HT29). The relative cell survival progressively decreased in dose dependant manner. In addition to that, Short term Cytotoxicity studies by Tryphan Blue exclusion method also confirmed the anticancer activity of vernonia cinerea L. (1mg/ml showed 77% of Cytotoxicity inhibition). Our studies point the possibility of developing Vernonia cinerea L. as a novel potential agent in the area of cancer chemotherapy. Further investigation has to be carried out in isolation and characterization of active constituents and the mechanism involving in antitumor and cytotoxic effect.

In the present work to the synthesis of three piperazine derivatives by using different aldehydes. The physical characterizations like molecular weight, melting point, Rf value and solubility of the synthesized compounds will be determined. The synthesized compounds will be subjected for Anti- helminthic evaluation.

Reproduction is the no blest and most reverent of all human powers. God has given this precious gift to the women. Motherhood is the cherished desire deep down in the heart of every women. Failure to achieve conception is known as Maladu (infertility). Even in the computer age, it is estimated that nearly 10-15% of couples are infertile in India. The ancient system of siddha medicine advocated variety of medication, which provides good results without any harmful effect. The main causes of infertility are tubal block, PCOD, PID and endometriosis. Bringing Tridhos as into its equilibrium state Treatment of Malatu puzhu at the time of menstruation on the first three days of cycle. Administration of internal medicine with suitable anupanam.

Now-a-days administration from oral route is getting more passive of about 75%, when compared to the drugs that are administrated from various parts of body. And novel formulation using the disintegrates leads to a new type of dosage form i.e. Oral disintegrating tablets and these are peak in demand from few decades due to their rapid disintegration followed to dissolution. These are directly disintegrated in the mouth within seconds (25-40 seconds).Without the help of the water only oral mucosa is enough for the dissolution of the tablet. The selection of disintegrating agent is also required to get optimum bio-availability and Disintegrates might be single or many for a preparation to ensure maximum disintegration and bio availability. This is also known as orodisintegration tablet. Disintegrating agents are used very rarely in solid unit dosage forms nearly 1-10% of their total dosage unit. These super disintegrates improve the efficacy of drug by rapid dissolution and various disintegrates and super disintegrates, excipients are used in formulation of ODT. Here in this review article we are going to overview about of various disintegrates like natural, polymer, synthetic. And formulation methods, applications and various parameters of ODT’s. These are completely likeable to the patients of pediatrics and generics. ODT’s are highly preferred in the treatment of the dysphagia and the patients of oral disorders.

Recently the research and analysis of green nanoparticles (NPs) synthesized with plant extracts has been expanded significantly due to their great biological activities. From the variety of agents used for nanoparticles synthesis, silver (Ag) is the most preferred due to its recommended use in medical field as best topical bactericides from ancient times. In the present project, crude bark extracts of Acacia auriculiformis A. Cunn. were used for nanoparticles synthesis and comparison of their biochemistry with crude extract was assessed by using biochemistry analytical techniques viz; UV-Visible spectrophotometer (UV-Vis), Fourier transform infra-red spectrophotometer (FTIR), Photoluminescence (PL) and Direct Light Scattering analysis (DLS).

Lactation failure has become more common in females nowadays due to lifestyle modifications. Increased stress in working women, intake of junk foods have contributed to nutritional deficiencies and hormonal imbalances which ultimately leads to lactation failure. Galactagogues are those herbs, supplements or drugs that can increase the secretion or production of milk. In general, galactagogues are used to treat lactation failure or deficiency, also known as agalactia or hypogalactia, respectively. Some synthetic drugs used to treat lactation failure are metoclopramide and domperidone. Their remarkable side effects in mothers are xerostomia (dry mouth syndrome or hypo salivation), gastrointestinal disorders, cardiac arrhythmia, lethargy, sedation, extra pyramidal symptoms such as hypertension, tremor, tic, facial seborrhea, hyperhidrosis and even sudden death. In infants who ingested the milk from treated mothers develop intestinal discomfort, lethargy and sedation. The aim of this review is to highlight the galactagogue action of herbs used in siddha system of medicine. Many herbs possess galactagogue activity. But this donot cause the side effects mentioned above. The use of herbs in treating diseases is growing because of society’s interest. This review may give a good reference in selection of medicinal plants with galactagogue activity.

Semiorganic L-Valine doped Lithium Hydrogen Phthalate (LHP) crystals were grown by conventional Slow Evaporation Solution Growth Technique (SEST). Single Crystal XRD provides information regarding the cell parameters. The spectral properties and the presence of functional groups were analyzed FTIR spectral analysis. UV-Vis-NIR spectral analysis suggests that the title material is transparent in the visible region without any strong absorptions. The TG/DTA thermogram provides information regarding the thermal stability of the material. Vicker’s microhardness test suggests that the title material is mechanically stable up to 100g.

Aims: The objective of the present research study was development of fast disintegrating tablets that dissolve or disintegrate rapidly in the saliva, within a few seconds, without the need for water. They have proved to be ideal for geriatric and paediatric population, people suffering from dysphagia, bedridden, mentally ill, nauseated and uncooperative patients, clinical conditions where water is not available and for drugs undergoing high first pass metabolism. Fast disintegrating tablets are also ideal for active people due to its advantages like faster onset of action, avoidance of first pass metabolism, taste masking of bitter drugs, improvement in solubility of poorly soluble drugs by inclusion complex formation and ultimately bioavailability enhancement of low bio available drugs. Study Design: Design and development of formulation includes short listing of ingredients for the formulation, effect of various process as well as formulation parameters of by direct compression method. Characterization of fast disintegrating tablet is done by weight variation, Thickness, Hardness, Friability, Disintegration time, wetting time, Drug content, Water absorption ratio, In-vitro dissolution studies and drug release kinetic.

Undoped and methyl orange doped KAP crystals were grown by slow evaporation solution growth technique. The grown crystals were subjected to single crystal and powder x-ray diffraction analysis in order to estimate the structural parameters. The presence of functional groups and the spectral properties were assessed by FTIR analysis. The optical properties were examined by UV-Visible spectral analysis. The thermal stability and the mechanical stability were evaluated by TG/DTA and Vicker’s micro hardness test respectively. NLO studies provide information regarding the SHG efficiency of the specimens and the results suggest that methyl orange doped KAP crystals are potential candidates for NLO device applications.

L- Cysteine ethyl ester hydrochloride (LCEEHCL) is a semi organic crystal grown by conventional Slow Evaporation Solution Growth technique. The crystal structure was determined at room temperature by single crystal X-Ray diffraction method. The phase analysis of the grown crystal was studied using powder x-ray diffraction. The vibrational frequencies of various functional groups have been obtained from FTIR spectrum. The optical property was examined by UV-Visible spectral analysis. The thermal and mechanical behaviours were investigated by TG/DTA and Vicker’s micro hardness test respectively. The nonlinear optical properties of the title compound were observed by measuring the SHG efficiency, which is 1.5 times to that of KDP by Kurtz and Perry powder technique. Particle size dependency analysis suggests that the title material possesses phase matching behavior. Photo luminescence spectrum showed sharp green emission band centered around 592 nm. The results suggest that the title material is an ideal candidate in enhancing the frequency of nonlinear optical devices.