Ciprofloxacin HCL is an effervescent Tablet is made by Wet Granulation Method. Ciprofloxacin is a broad spectrum Fluroquinolon antibiotics. Is mainly used for various Bacterial Infections. In this tablet bitter taste was masked by saccharine as sweeting agent furthermore the effervescent effect of citric acid, tartaric acid and sodium bicarbonate lead to Effervescent activity by realising the CO2 Molecule. Tablets are rapidly dissolved and rapidly absorbed and give maximum activity. The Prepared Effervescent Tablet is Evaluated In terms of bulk density, tapped density, angle of repose, Carr’s Index and, hardness test, weight variation test, friability test and in vitro study. The result associated in Optimized batch is good to Satisfactory and having a good free flowing property. The hardness, weight variation, and friability these values are within the pharmacopeia limit. The in vitro Dissolution studies show Maximum percentage of release of drug (99.26) with in end of 5 min.

Among the various novel drug delivery systems the fast dissolving drug delivery system is rapidly gaining interest in pharmaceutical Industry. Fast-dissolving drug-delivery systems were first developed in the late 1970 as an alternative to tablets, capsules, and for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. These are used in the form of fast dissolving tablet and fast dissolving oral films. Today, fast dissolving drug delivery system is a proven and accepted technology for the systemic delivery of active pharmaceutical ingredient for over-the-counter medications. Fast dissolving drug delivery has become a significant priority worldwide. It can be easily swallowed without requirement of water is a major advantage over conventional dosage form. It may be possible to achieve rapid absorption of drugs and increased bioavailability, reduced toxicity, rapid onset of therapeutic action, improved delivery of poorly water-soluble drugs and also it is regarded as the most economical and safest method of drug delivery.

This paper, we present the systematic calculation of the Heterogeneous nanotubes band gap based on its bond length and geometry’s of nanotubes we used selected heterogeneous nanotubes and integers for Zig Zag, Armchair, Chiral geometries for calculation. Energy gap variation is not large and it varies inversely with nanotubes diameter, as predicted by theory. The band gap is calculated with the all three geometries using integers and it’s compared with the each geometries. Possible explanation for the band gap variation in heterogeneous nanotubes is given using a mathematical calculation.

In the present study, bio synthesis of silver Nanoparticles using aqueous leaf extract of Acalypha indica and its anti-inflammatory activity against different micro-organisms were investigated. About 10 ml of aqueous extract of A. indica is added with 90 ml of AgNo3 (1mM) solution, the resulting mixture was incubated at 370C under static condition. After a period of 30 minutes the colour of the mixture changes from yellow to brownish colour, which indicates the formation of AgNPs. Green synthesis of silver nanoparticles (AgNPs) was characterized by UV-visible spectroscopy, Transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction (XRD). The Ag-Nps are monitored with the help of UV-visible spectrophotometer at the range of wavelength of 267.95nm. The average size of Ag-Nps was found to be 16.86 nm and 16.6 nm determined by using XRD and TEManalysis respectively. The technique was employed to visualize the size of Ag-Nps. It is observed from the results that biologically synthesized Ag-Nps from Acalypha indica aqueous leaf extract showed effective anti-inflammatory activity against human blood cells when comparable with standard values.

Bovine serum albumin nanoparticles (BSANPs) are safe and biocompatible biocarrier systems used for site specific drug delivery. BSANPs are going to be used as the standard low-cost and safe nanobiomaterials for improved drug loading capacity for loaded bioactive molecules. Size controlling of BSANPs is very crucial step that make these NPs more safe and potent nanobiovehicles to get controlled and sustained targeted drug delivery. In this work, BSANPs were prepared by modified desolvation process using butanol-toluene to get most controllable particle size at nanoscale. DLS (Dynamic Light Scatting) was used to characterize the purity and size distribution of the prepared BSANPs. The prepared BSANPs were found to attained size range from 10 nm to 20 nm with exhibited diameter up to 12 nm and width of 0.9 nm which are observed to have the best narrow size distribution at nanoscale considerations. Hence, this proposed desolvation method can be a safe and low-cost technology to prepare ulta-fine sized BSANPs and diameter which may prove effective drug and gene delivery nonviral vehicles.