The objective of this research was to formulate a cream for the treatment of cracked Heels using Hibiscus leaves extract and Aloe Vera as a key ingredient. The cream formulation, comprising Hibiscus leaves extract, Aloe vera juice, coconut oil and beeswax was prepared and evaluated for various parameters including physical evaluation, pH, spread-ability, stability, viscosity and washability. The used product is compatible with other ingredients present in the formulation.

Pyrazinamide remains an essential antitubercular agent; however, its clinical application is often limited by rapid metabolism and dose-related toxicity. In the present investigation, a polymer-based nanosuspension system was designed to improve oral delivery and sustain drug release. Pyrazinamide nanosuspensions were formulated using cellulose acetate and a non-ionic stabilizer through a solvent displacement method, followed by chitosan surface modification. The formulations were evaluated for physicochemical properties, in vitro release behavior, compatibility and stability. The optimized formulation demonstrated nanoscale particle size, high drug encapsulation and prolonged release over 24 h, indicating its potential for improved oral therapy.