Our present study is to formulate a antidiabetic herbal capsule dosage form having highly effective, least side effect and more dose accuracy. Our study focuses on preparation of herbal capsule which has antidiabetic activity by combination of herbal drugs Withania Coagulans, fenugreek, curcumin and ginger. The raw Withania Coagulans fruits and Fenugreek seeds is dried and triturate for increase the surface area of powder during dissolution and the powder of curcumin and ginger was taken. The powder which has been prepared have less dose accuracy and bitter taste during the direct consumption  to overcome this limitations powder is filled in capsule shell which can retain the 300mg of powder. The capsule gets disintegrated in 3 to 4 minutes and the drug is released during the dissolution within a period of 1 hour.

Ocular drug delivery remains significant challenges due to the unique anatomy and physiology of the eye, which limits drug penetration and bioavailability. It has numerous barriers the major barriers includes the precorneal tear flim, corneal epithelium, conjunctival clearance, blood-aqueous barrier and blood-retinal barrier. These protective mechanisms restrict drug absorption necessary for frequent dosing and leading to suboptimal therapeutic outcomes. The metabolism of cornea and lens and regulation of intra-ocular fluids are directly influenced by blood-aqueous barrier. It includes various routes of adminstration in ocular drug delivery system as topical (eye drops) intraviteral, periocular and systemic drug delivery system enhance the drug penetration. This review mainly explores the advantages, disadvantages and application various field that improved bioavailability, sustained drug release, enhanced permeation and has mainly influenced targeted therapy. The articles provides an overview of ocular drug delivery.